Therapeutic potential of folate uptake inhibition in Plasmodium falciparum
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Date
2004Author
Nzila, AM
Kokwaro, G
Winstanley, PA
Marsh, K
Ward, SA
Advisor
Type
ArticleLanguage
enMetadata
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Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo
URI
http://www.ncbi.nlm.nih.gov/pubmed/16676416http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30815
Citation
Trends Parasitol. 2004 Mar;20(3):109-12Publisher
University of Nairobi College of Humanities Sciences
Collections
- Faculty of Health Sciences (FHS) [10378]