Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans.
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Date
1988Author
Jacobson, LA,
Jen-Jacobson, L
Hawdon, JM
Owens GP, GP
Shah, MV
et al
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Mutants of Caenorhabditis elegans having about 10% of wild-type activity of the aspartyl protease cathepsin D have been isolated by screening. Mutant homozygotes have normal growth rates and no obvious morphological or developmental abnormalities. The mutant gene (cad-1) has been mapped to the right extremity of linkage group II. Heterozygous animals (cad-1/+) show intermediate enzyme levels and animals heterozygous for chromosomal deficiencies of the right extremity of linkage group II have 50% of wild-type activity. Cathepsin D purified from a mutant strain has a lower activity per unit mass of pure enzyme. These data suggest that cad-1 is a structural gene for cathepsin D.
URI
www.ncbi.nlm.nih.gov/whalecom0/pubmed/3396869http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30991
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203418/
Citation
Genetics. 1988 Jun;119(2):355-63.Publisher
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
Collections
- Faculty of Health Sciences (FHS) [10378]