dc.contributor.author | Jacobson, LA, | |
dc.contributor.author | Jen-Jacobson, L | |
dc.contributor.author | Hawdon, JM | |
dc.contributor.author | Owens GP, GP | |
dc.contributor.author | Shah, MV | |
dc.contributor.author | et al | |
dc.date.accessioned | 2013-06-10T14:29:37Z | |
dc.date.available | 2013-06-10T14:29:37Z | |
dc.date.issued | 1988 | |
dc.identifier.citation | Genetics. 1988 Jun;119(2):355-63. | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/whalecom0/pubmed/3396869 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30991 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203418/ | |
dc.description.abstract | Mutants of Caenorhabditis elegans having about 10% of wild-type activity of the aspartyl protease cathepsin D have been isolated by screening. Mutant homozygotes have normal growth rates and no obvious morphological or developmental abnormalities. The mutant gene (cad-1) has been mapped to the right extremity of linkage group II. Heterozygous animals (cad-1/+) show intermediate enzyme levels and animals heterozygous for chromosomal deficiencies of the right extremity of linkage group II have 50% of wild-type activity. Cathepsin D purified from a mutant strain has a lower activity per unit mass of pure enzyme. These data suggest that cad-1 is a structural gene for cathepsin D. | en |
dc.language.iso | en | en |
dc.title | Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans. | en |
dc.type | Article | en |
local.publisher | Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260. | en |