Myelodysplastic syndromes (MDS) in Central Africans
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Date
1994Author
Mukiibi, JM
Paul, B
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Forty two patients who were seen and satisfied the French-American-British (FAB) diagnostic criteria for myelodysplastic syndromes (MDS) over a 6-year period at the University of Zimbabwe's Department of Haematology, Harare, are presented. Their overall ages ranged from 29 to 75 years with a mean +/- SD of 57.8 +/- 11.2 years. Males outnumbered females with a male to female ratio of 1.2:1. Refractory anaemia (RA) occurred in 33.3%; refractory anaemia with ringed sideroblasts (RARS) in 16.7%; refractory anaemia with excess blasts (RAEB) in 21.4%; refractory anaemia with excess blasts in transformation (RAEB-T) in 16.7% and chronic myelomonocytic leukaemia (CMML) in 11.9% of the patients. In 90.5% the disease was primary and in 9.5% prior exposure to myelotoxic agents resulted in secondary MDS. The study reveals that MDS as a cause of anaemia in the African population is usually hidden in the big number of well known anaemias due to rampant malaria, malnutrition and a host of nutritional deficiencies. There is therefore the need to increase diagnostic awareness among our clinicians about the existence of these disorders
URI
http://www.ncbi.nlm.nih.gov/pubmed/8165730http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31072
Citation
Trop Geogr Med. 1994;46(1):17-9.Publisher
University of Nairobi Department of Haematology and Blood Transfusion
Collections
- Faculty of Health Sciences (FHS) [10377]