A comparison of single-dose spectinomycin with five days of trimethoprim-sulfamethoxazole for the treatment of chancroid
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Date
1987-06Author
Fransen L
Nsanze H
Ndinya-Achola JO
D'Costa L
Ronald AR
Piot P
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In a controlled trial 32 patients with ulcers culture-positive for Haemophilus ducreyi were treated with a single 2-g dose of spectinomycin, and 20 patients were treated with a five-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 160/800 mg) twice daily. Both regimens rapidly eradicated H. ducreyi from ulcers, with subsequent healing of ulcers and buboes. The cure rates 14 days after initiation of therapy were 94% for spectinomycin and 95% for TMP-SMZ. Patients with H. ducreyi-negative ulcers who were treated with the same regimens also healed and did not show a significantly different efficacy for either regimen. Thus we found that the one-day regimen of spectinomycin was as effective for the treatment of chancroid as was TMP-SMZ given for five days. Further studies on a larger number of patients are needed to confirm our findings.
URI
http://www.ncbi.nlm.nih.gov/pubmed/2956702http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31116
Citation
Sex Transm Dis. 1987 Apr-Jun;14(2):98-101.Publisher
University of Nairobi Department of Medicine
Collections
- Faculty of Health Sciences (FHS) [10378]