dc.contributor.author | Fransen L | |
dc.contributor.author | Nsanze H | |
dc.contributor.author | Ndinya-Achola JO | |
dc.contributor.author | D'Costa L | |
dc.contributor.author | Ronald AR | |
dc.contributor.author | Piot P | |
dc.date.accessioned | 2013-06-11T06:39:48Z | |
dc.date.available | 2013-06-11T06:39:48Z | |
dc.date.issued | 1987-06 | |
dc.identifier.citation | Sex Transm Dis. 1987 Apr-Jun;14(2):98-101. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2956702 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31116 | |
dc.description.abstract | In a controlled trial 32 patients with ulcers culture-positive for Haemophilus ducreyi were treated with a single 2-g dose of spectinomycin, and 20 patients were treated with a five-day course of trimethoprim-sulfamethoxazole (TMP-SMZ; 160/800 mg) twice daily. Both regimens rapidly eradicated H. ducreyi from ulcers, with subsequent healing of ulcers and buboes. The cure rates 14 days after initiation of therapy were 94% for spectinomycin and 95% for TMP-SMZ. Patients with H. ducreyi-negative ulcers who were treated with the same regimens also healed and did not show a significantly different efficacy for either regimen. Thus we found that the one-day regimen of spectinomycin was as effective for the treatment of chancroid as was TMP-SMZ given for five days. Further studies on a larger number of patients are needed to confirm our findings. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | A comparison of single-dose spectinomycin with five days of trimethoprim-sulfamethoxazole for the treatment of chancroid | en |
dc.type | Article | en |
local.publisher | Department of Medicine | en |