Mn2+ prevents the Ca2+-induced inhibition of ATP synthesis in brain mitochondria
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Date
1983-04Author
Hillered, L
Muchiri, PM
Nordenbrand, K
Ernster, L
Connell, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Uptake of Ca2+ by rat brain mitochondria causes an inhibition of respiratory stimulation by ADP, and the inhibition is relieved upon Na+-induced release of Ca2+ from the mitochondria, in accordance with earlier reports. We show that simultaneous uptake of Ca2+ and Mn2+ results in no inhibition of ADP-stimulated respiration, indicating that Mn2+ prevents the Ca2+-induced inhibition of ATP synthesis, without preventing Ca2+ accumulation in the mitochondria. The results are discussed in relation to a possible involvement of the mitochondrial ATPase-inhibitor protein in the observed effects of Ca2+ and Mn2+.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/?term=Muchiri+PMhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/31719
Citation
FEBS Lett. 1983 Apr 18;154(2):247-50.Publisher
University of Nairobi School of Medicine, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]