Effect of halothane on cardiovascular and plasma catecholamine responses to tracheal intubation
View/ Open
Date
1986-12Author
Turner, DA
Shribman, AJ
Smith, G
Achola, KJ
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The catecholamine and cardiovascular responses to intubation were investigated during halothane anaesthesia. Thirty patients were allocated randomly to two groups. Following induction of anaesthesia and muscle relaxation, group 1 was ventilated with 70% nitrous oxide in oxygen before intubation; group 2 received 1% halothane in addition. After intubation, both groups received 0.5% halothane. Arterial pressure and heart rate, and plasma noradrenaline and adrenaline concentrations were measured throughout the induction sequence. In group 1 intubation was associated with increases (from pre-induction values) in systolic arterial pressure of 13% and diastolic arterial pressure of 35%, although the plasma concentrations of noradrenaline did not alter significantly. In group 2, although there was a pressor response to intubation, no overall change in systolic arterial pressure and only a 13% increase in diastolic arterial pressure occurred when compared with pre-induction values. This response was associated with a 78% increase in the noradrenaline concentration; the adrenaline concentration did not alter significantly.
URI
http://www.ncbi.nlm.nih.gov/pubmed/3790388http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32057
Citation
Br J Anaesth. 1986 Dec;58(12):1365-70.Publisher
University of Nairobi, School of Medicine, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]