Risk factors for cardiac dysfunction in children on treatment for cancer at Kenyatta National Hospital, Nairobi.
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Date
2009-12Author
Shiroya-Wandabwa M.
Yuko-Jowi C.
Nduati RW.
Githanga Jessie N.
Wamalwa D.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVE:
To determine the point prevalence of abnormal cardiac function and to assess the risk factors for cardiac dysfunction in paediatric oncology patients on treatment at Kenyatta National Hospital.
DESIGN:
Descriptive cross-sectional study with a nested case control.
SETTING:
Kenyatta National Hospital between February and April 2006.
MAIN OUTCOME MEASURES:
Left ventricular dysfunction if ejection fraction (EF) <55% or fractional shortening (FS) <29% defined cases. Controls had EF >55% or FS >29%.
RESULTS:
One hundred and eleven patients were enrolled of whom 32 had abnormal cardiac function and were classified as cases while 79 had normal cardiac function. About a third, point prevalence 29% (95% CI 21.2-37.9), had cardiac dysfunction. Cumulative anthracycline dose was a risk factor for cardiac dysfunction in this population. Above 200 mg/m2 the attributable risk percentage of cardiac dysfunction was 77%.
CONCLUSIONS:
Serial echocardiography should be performed to identify patients at risk. Alternative treatment protocols should be used when the cumulative anthracycline dose exceeds 200 mg/m2 due to the high attributable risk. Studies to further assess the other associated risk factors and long term effects of anthracycline are recommended.
URI
http://www.ncbi.nlm.nih.gov/pubmed/21591510http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32141
Citation
East Afr Med J. 2009 Dec;86(12 Suppl):S52-7Publisher
University of Nairobi. Department of Medicine
Collections
- Faculty of Health Sciences (FHS) [10378]