dc.contributor.author | Shiroya-Wandabwa M. | |
dc.contributor.author | Yuko-Jowi C. | |
dc.contributor.author | Nduati RW. | |
dc.contributor.author | Githanga Jessie N. | |
dc.contributor.author | Wamalwa D. | |
dc.date.accessioned | 2013-06-12T09:40:33Z | |
dc.date.available | 2013-06-12T09:40:33Z | |
dc.date.issued | 2009-12 | |
dc.identifier.citation | East Afr Med J. 2009 Dec;86(12 Suppl):S52-7 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/21591510 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32141 | |
dc.description.abstract | OBJECTIVE:
To determine the point prevalence of abnormal cardiac function and to assess the risk factors for cardiac dysfunction in paediatric oncology patients on treatment at Kenyatta National Hospital.
DESIGN:
Descriptive cross-sectional study with a nested case control.
SETTING:
Kenyatta National Hospital between February and April 2006.
MAIN OUTCOME MEASURES:
Left ventricular dysfunction if ejection fraction (EF) <55% or fractional shortening (FS) <29% defined cases. Controls had EF >55% or FS >29%.
RESULTS:
One hundred and eleven patients were enrolled of whom 32 had abnormal cardiac function and were classified as cases while 79 had normal cardiac function. About a third, point prevalence 29% (95% CI 21.2-37.9), had cardiac dysfunction. Cumulative anthracycline dose was a risk factor for cardiac dysfunction in this population. Above 200 mg/m2 the attributable risk percentage of cardiac dysfunction was 77%.
CONCLUSIONS:
Serial echocardiography should be performed to identify patients at risk. Alternative treatment protocols should be used when the cumulative anthracycline dose exceeds 200 mg/m2 due to the high attributable risk. Studies to further assess the other associated risk factors and long term effects of anthracycline are recommended. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Risk factors for cardiac dysfunction in children on treatment for cancer at Kenyatta National Hospital, Nairobi. | en |
dc.type | Article | en |
local.publisher | Department of Medicine | en |