Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression.
Date
2009-10Author
Piantadosi, A
Panteleeff, D
Blish, CA
Baeten, JM
Jaoko Walter G.
McClelland, RS
Overbaugh, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naïve Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4(+) T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection.
URI
www.ncbi.nlm.nih.gov/whalecom0/pubmed/19640996http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32497
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748011/
Citation
J Virol. 2009 Oct;83(19):10269-74. doi: 10.1128/JVI.01149-09. Epub 2009 Jul 29Publisher
University of Nairobi School of medicine,University of Nairobi Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Kenya
Collections
- Faculty of Health Sciences (FHS) [10377]