dc.contributor.author | Piantadosi, A | |
dc.contributor.author | Panteleeff, D | |
dc.contributor.author | Blish, CA | |
dc.contributor.author | Baeten, JM | |
dc.contributor.author | Jaoko Walter G. | |
dc.contributor.author | McClelland, RS | |
dc.contributor.author | Overbaugh, J | |
dc.date.accessioned | 2013-06-12T15:04:45Z | |
dc.date.available | 2013-06-12T15:04:45Z | |
dc.date.issued | 2009-10 | |
dc.identifier.citation | J Virol. 2009 Oct;83(19):10269-74. doi: 10.1128/JVI.01149-09. Epub 2009 Jul 29 | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/whalecom0/pubmed/19640996 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32497 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748011/ | |
dc.description.abstract | The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naïve Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4(+) T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression. | en |
dc.type | Article | en |
local.publisher | School of medicine,University of Nairobi | en |
local.publisher | Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Kenya | en |