A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni.
dc.contributor.author | Colley, DG | |
dc.contributor.author | Binder, S | |
dc.contributor.author | Campbell, C | |
dc.contributor.author | King, CH | |
dc.contributor.author | Tchuem, Tchuenté LA | |
dc.contributor.author | N'Goran, EK | |
dc.contributor.author | Erko, B | |
dc.contributor.author | Karanja, DM | |
dc.contributor.author | Kabatereine, NB | |
dc.contributor.author | van, Lieshout L | |
dc.contributor.author | Rathbun, S | |
dc.date.accessioned | 2013-06-13T07:10:13Z | |
dc.date.available | 2013-06-13T07:10:13Z | |
dc.date.issued | 2013-03 | |
dc.identifier.citation | Am J Trop Med Hyg. 2013 Mar;88(3):426-32 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23339198 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32702 | |
dc.description.abstract | We evaluated a commercial point-of-care circulating cathodic antigen (POC-CCA) test for assessing Schistosoma mansoni infection prevalence in areas at risk. Overall, 4,405 school-age children in Cameroon, Côte d'Ivoire, Ethiopia, Kenya, and Uganda provided urine for POC-CCA testing and stool for Kato-Katz assays. By latent class analysis, one POC-CCA test was more sensitive (86% versus 62%) but less specific (72% versus ~100%) than multiple Kato-Katz smears from one stool. However, only 1% of POC-CCA tests in a non-endemic area were false positives, suggesting the latent class analysis underestimated the POC-CCA specificity. Multivariable modeling estimated POC-CCA as significantly more sensitive than Kato-Katz at low infection intensities (< 100 eggs/gram stool). By linear regression, 72% prevalence among 9-12 year olds by POC-CCA corresponded to 50% prevalence by Kato-Katz, whereas 46% POC-CCA prevalence corresponded to 10% Kato-Katz prevalence. We conclude that one urine POC-CCA test can replace Kato-Katz testing for community-level S. mansoni prevalence mapping | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni. | en |
dc.type | Article | en |
local.publisher | College of Health Sciences | en |
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