Human immunodeficiency virus-related microvasculopathy and Kaposi's sarcoma: a case-control study.
View/ Open
Date
1995-07Author
Baumann, S
Geier, SA
Thoma-Gerber, E
Noehl, MA
Klauss, V
Goebel, FD
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Ocular microangiopathic syndrome including retinal and conjunctival abnormalities is frequently found in patients with human immunodeficiency virus type 1 (HIV-1) disease. Kaposi's sarcoma (KS) is the most frequent neoplasia found in patients with HIV-1 disease. We have recently reported a significant association between conjunctival microvasculopathy and KS in 117 patients with HIV-1 disease. The objective of the present study was to determine whether this association is existent when matched patients with and without KS are compared. A total of 22 matched pairs were obtained under consideration of the absolute CD4+ lymphocyte count, Walter Reed (WR) classification, gender, and serum levels of beta-2-microglobulin and neopterin. Conjunctival microangiopathy was determined for each eye by a standardized rating scale ranging from 0 to 5, allowing a reliable and valid quantification of conjunctival blood-flow sludging. The mean value obtained for conjunctival sludge was 1.8 (SEM, 0.4) for patients without KS and 3.2 (SEM, 0.3) for patients with KS, demonstrating a clinically and statistically significant difference between the two groups (Student's t = 3.0; P = 0.003). This difference was higher when patients with a CD4+ lymphocyte count exceeding 200/microliters were regarded. Similar factors or mechanisms may contribute to HIV-related conjunctival microvasculopathy and KS.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/7492937http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35617
Citation
Ger J Ophthalmol. 1995 Jul;4(4):239-45.Publisher
University of Nairobi College of Health Sciences,University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]