dc.contributor.author | Baumann, S | |
dc.contributor.author | Geier, SA | |
dc.contributor.author | Thoma-Gerber, E | |
dc.contributor.author | Noehl, MA | |
dc.contributor.author | Klauss, V | |
dc.contributor.author | Goebel, FD | |
dc.date.accessioned | 2013-06-18T12:19:03Z | |
dc.date.available | 2013-06-18T12:19:03Z | |
dc.date.issued | 1995-07 | |
dc.identifier.citation | Ger J Ophthalmol. 1995 Jul;4(4):239-45. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/7492937 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35617 | |
dc.description.abstract | Ocular microangiopathic syndrome including retinal and conjunctival abnormalities is frequently found in patients with human immunodeficiency virus type 1 (HIV-1) disease. Kaposi's sarcoma (KS) is the most frequent neoplasia found in patients with HIV-1 disease. We have recently reported a significant association between conjunctival microvasculopathy and KS in 117 patients with HIV-1 disease. The objective of the present study was to determine whether this association is existent when matched patients with and without KS are compared. A total of 22 matched pairs were obtained under consideration of the absolute CD4+ lymphocyte count, Walter Reed (WR) classification, gender, and serum levels of beta-2-microglobulin and neopterin. Conjunctival microangiopathy was determined for each eye by a standardized rating scale ranging from 0 to 5, allowing a reliable and valid quantification of conjunctival blood-flow sludging. The mean value obtained for conjunctival sludge was 1.8 (SEM, 0.4) for patients without KS and 3.2 (SEM, 0.3) for patients with KS, demonstrating a clinically and statistically significant difference between the two groups (Student's t = 3.0; P = 0.003). This difference was higher when patients with a CD4+ lymphocyte count exceeding 200/microliters were regarded. Similar factors or mechanisms may contribute to HIV-related conjunctival microvasculopathy and KS. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Human immunodeficiency virus-related microvasculopathy and Kaposi's sarcoma: a case-control study. | en |
dc.type | Article | en |
local.publisher | College of Health Sciences,University of Nairobi | en |