Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron
Date
1990-01Author
Bories JC.
Loiseau P.
d'Auriol L.
Gontier Christopher Stuart.
Bensussan A.
Degos L.
Sigaux F.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We have defined transcriptional enhancing sequences inside the TCR-delta gene locus, using transient transfections with constructs containing DNA fragments cloned upstream to a reporter gene fused to a heterologous promoter. A 14-kb DNA region extending from the J delta 3 segment to 6 kb 3' to C delta was analyzed. We show the presence of positive regulatory sequences inside the J delta 3-C delta intron and have localized these sequences to two DNA fragments of approximately 300 and 258 bp. Analysis of cell specificity of the activation of such sequences demonstrates a T cell pattern for one of the two fragments. The nucleotide sequence of the T cell-specific element shows motifs sharing homology with previously described core enhancers.
URI
http://profiles.uonbi.ac.ke/christophergontier/publications/bories-jc-loiseau-p-dauriol-l-gontier-c-bensussan-degos-l-sigaux-f-rhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/38421
http://www.ncbi.nlm.nih.gov/pubmed/2295883
Citation
STUART, DRGONTIERCHRISTOPHER. 1990. Bories JC, Loiseau P, d'Auriol L, Gontier C, Bensussan A, Degos L, Sigaux F. Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron.J Exp Med. 199. J Exp Med. 1990 Jan 1;171(1):75-83Publisher
Department of Human Pathology, College of Health Sciences, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]