dc.contributor.author | Bories JC. | |
dc.contributor.author | Loiseau P. | |
dc.contributor.author | d'Auriol L. | |
dc.contributor.author | Gontier Christopher Stuart. | |
dc.contributor.author | Bensussan A. | |
dc.contributor.author | Degos L. | |
dc.contributor.author | Sigaux F. | |
dc.date.accessioned | 2013-06-23T08:54:45Z | |
dc.date.available | 2013-06-23T08:54:45Z | |
dc.date.issued | 1990-01 | |
dc.identifier.citation | STUART, DRGONTIERCHRISTOPHER. 1990. Bories JC, Loiseau P, d'Auriol L, Gontier C, Bensussan A, Degos L, Sigaux F. Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron.J Exp Med. 199. J Exp Med. 1990 Jan 1;171(1):75-83 | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/christophergontier/publications/bories-jc-loiseau-p-dauriol-l-gontier-c-bensussan-degos-l-sigaux-f-r | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/38421 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2295883 | |
dc.description.abstract | We have defined transcriptional enhancing sequences inside the TCR-delta gene locus, using transient transfections with constructs containing DNA fragments cloned upstream to a reporter gene fused to a heterologous promoter. A 14-kb DNA region extending from the J delta 3 segment to 6 kb 3' to C delta was analyzed. We show the presence of positive regulatory sequences inside the J delta 3-C delta intron and have localized these sequences to two DNA fragments of approximately 300 and 258 bp. Analysis of cell specificity of the activation of such sequences demonstrates a T cell pattern for one of the two fragments. The nucleotide sequence of the T cell-specific element shows motifs sharing homology with previously described core enhancers. | en |
dc.language.iso | en | en |
dc.title | Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron | en |
dc.type | Article | en |
local.publisher | Department of Human Pathology, College of Health Sciences, University of Nairobi | en |