dc.contributor.author | Njagi, J. K. | |
dc.contributor.author | Estambale, B. B. A. | |
dc.contributor.author | Magnussen, P. | |
dc.contributor.author | Ouma, J. H. | |
dc.contributor.author | Rapuoda, B. A. | |
dc.contributor.author | Kabiru, E. W. | |
dc.date.accessioned | 2013-06-27T15:20:10Z | |
dc.date.available | 2013-06-27T15:20:10Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | East African medical journal | en |
dc.identifier.uri | http://cat.inist.fr/?aModele=afficheN&cpsidt=1734864 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41291 | |
dc.description.abstract | A study on the comparative efficacy of two antimalarial drugs, namely chloroquine and sulfadoxine/pyrimethamine combination in the treatment of falciparum malaria was carried out in Siaya District, Nyanza Province of Kenya. Children aged between six to sixty months attending Bondo sub-district hospital with a history of fever within 48 hours were screened for malaria parasites. Those found to have a parasite density of ≥1000 parasites/μl of blood were recruited and randomly allocated to two treatment regimens comprising of chloroquine at a total dose of 25mg/kg body weight given for three days and sulfadoxine/pyrimethamine combination given as 25mg/kg of sulfadoxine and 1.25mg/kg of pyrimethamine as a single dose. The children were followed on days 3, 7 and 14. A total of 92 children met the inclusion criteria and were allocated to treatment with either chloroquine or sulfadoxine/pyrimethamine combination. Of those on chloroquine, parasite clearance on days 3, 7 and 14 was 31.1%, 44.4% and 42.3% respectively, while sulfadoxine/pyrimethamine combination had a clearance of 70.2%, 91.5% and 95.7% respectively. The differences in the parasite clearance on each follow up days for both drugs were statistically significant (p < 0.0001). Other parameters which included fever and packed cell volume (PCV) were seen to improve significantly for the sulfadoxine/pyrimethamine combination than for chloroquine | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol. 75, no. 8, pp. 446-449 (10 ref.); | |
dc.subject | Malaria | en |
dc.subject | Plasmodium falciparum | en |
dc.subject | Chemotherapy | en |
dc.subject | Chloroquine | en |
dc.subject | Drug combination | en |
dc.subject | Antimalarial | en |
dc.subject | Sulfadoxine | en |
dc.subject | Pyrimethamine | en |
dc.subject | Treatment | en |
dc.subject | Kenya | en |
dc.subject | Child | en |
dc.subject | Sulfanilamide derivatives | en |
dc.subject | Protozoal disease | en |
dc.title | Effectiveness of chloroquine and sulfadoxine/pyrimethamine combination in the treatment of falciparum malaria in a malaria endemic area of Kenya | en |
dc.type | Article | en |
local.publisher | Division of Vector Borne Diseases, Ministry of Health, P.O. Box 20750, Nairobi, KENYA | en |
local.publisher | Department of Medical Microbiology, Faculty of Medicine, University of Nairobi, Box 19676, Nairobi, KENYA | en |
local.publisher | Danish Bilharziasis Laboratory, Jaegersborg Alle ID, 2920 Charlottenlund, DANEMARK | en |
local.publisher | Department of Zoology, Kenyatta University, P.O. Box 43844, Nairobi, KENYA | en |