dc.contributor.author | Broliden, Kristina | |
dc.contributor.author | Hinkula, Jorma | |
dc.contributor.author | Devito, Claudia | |
dc.contributor.author | Kiama, Peter | |
dc.contributor.author | Kimani, Joshua | |
dc.contributor.author | Trabbatoni, Daria | |
dc.contributor.author | Bwayo, Job J. | |
dc.contributor.author | Clerici, Mario | |
dc.contributor.author | Plummer, Francis | |
dc.contributor.author | Kaul, Rupert | |
dc.date.accessioned | 2013-06-28T08:24:56Z | |
dc.date.available | 2013-06-28T08:24:56Z | |
dc.date.issued | 2001-11 | |
dc.identifier.citation | Immunology Letters | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/11595287 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/41616 | |
dc.description.abstract | Although HIV-specific cellular immune responses are found in a number of HIV highly-exposed, persistently seronegative (HEPS) cohorts, late seroconversion can occur despite pre-existing cytotoxic T lymphocytes (CTL), suggesting that a protective HIV vaccine may need to induce a broader range of HIV-specific immune responses. Low levels of HIV-specific IgA have been found in the genital tract and plasma of the majority of Nairobi HEPS sex workers and appeared to be independent of HIV-specific cellular responses. IgA purified from genital tract, saliva and plasma of most HEPS sex workers were able to neutralize infection of PBMC by a primary (NSI) clade B HIV isolate, as well as viral isolates from clades A and D, which predominate in Kenya. In addition, these IgA were able to inhibit transcytosis of infective HIV virions across a transwell model of the human mucosal epithelium in an HIV-specific manner. Preliminary work in other HEPS cohorts has suggested the recognition of different gp41 epitopes in HEPS and HIV-infected subjects. Although present at low levels, these IgA demonstrated cross-clade neutralizing activity and were able to inhibit HIV mucosal transcytosis, suggesting an important functional role in protection against HIV infection. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Volume 79, Issues 1–2, 1 November 2001, Pages 29–36; | |
dc.subject | HIV resistance | en |
dc.subject | Humoral immunity | en |
dc.subject | Neutralization | en |
dc.subject | Transcytosis | en |
dc.title | Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Nairobi, P.O. Box 19676, Nairobi, Kenya | en |
local.publisher | Department of Clinical Virology, F68, Karolinska Institute, Huddinge University Hospital, S-141 86 Stockholm, Sweden | en |
local.publisher | Department of Clinical Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, S-105 21 Stockholm, Sweden | en |
local.publisher | Chair of Immunology, University of Milan, Milan, Italy | en |
local.publisher | Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada | en |
local.publisher | MRC Human Immunology Unit, Institute of Molecular Medicine, Oxford, UK | en |