IL-7Ralpha expression on DC4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation
Date
2006Author
Koesters, SA
Alimonti, JB
Wachihi, C
Matu, L
ANZALA, O A
Kimani, J
Embree, JE
Plummer, FA
Fowke, KR
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Many factors can influence the rate of HIV disease progression, including those that maintain T cell homeostasis. One key homeostatic regulator is the IL-7 receptor (IL-7R). Previous studies have shown IL-7R expression levels decrease in HIV infection, but effects on memory subtypes, CD4+ T cells, and cell function have not been explored. The present study examined the expression of the IL-7R chain on naïve and memory T lymphocyte subsets of both HIV-positive and HIV-negative individuals from Nairobi, Kenya to assess the role of IL-7R in HIV disease. Expression of IL-7R was significantly reduced in all CD4+ and CD8+ T cell subsets in HIV-positive individuals. This reduction was further enhanced in those with advanced HIV progression. Expression of IL-7R was inversely correlated to immune activation, and apoptosis, and was positively correlated with CD4 count in both bivariate and multivariate analysis. Expression of IL-7R did not correlate with HIV viral loads, indicating the elevated immune activation seen in HIV-infected individuals may be impacting expression of IL-7R, independent of viral loads. Signaling via the IL-7R is essential for T cell homeostasis and maintenance of T cell memory. Reduction of this receptor may contribute to the homeostatic disruption seen in HIV.
Citation
O., PROFANZALAAGGREY. 2006. Koesters SA, Alimonti JB, Wachihi C, Matu L, ANZALA OA, Kimani J, Embree JE, Plummer FA, Fowke KR. IL-7Ralpha expression on DC4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Eur J Immunol. 2006 Feb;. Eur J Immunol. 2006 Feb;36(2):336-44.. : John Benjamins Publishing CompanyPublisher
University of nairobi College of health science
Collections
- Faculty of Health Sciences (FHS) [10378]