dc.contributor.author | Koesters, SA | |
dc.contributor.author | Alimonti, JB | |
dc.contributor.author | Wachihi, C | |
dc.contributor.author | Matu, L | |
dc.contributor.author | ANZALA, O A | |
dc.contributor.author | Kimani, J | |
dc.contributor.author | Embree, JE | |
dc.contributor.author | Plummer, FA | |
dc.contributor.author | Fowke, KR | |
dc.date.accessioned | 2013-06-29T09:55:05Z | |
dc.date.available | 2013-06-29T09:55:05Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | O., PROFANZALAAGGREY. 2006. Koesters SA, Alimonti JB, Wachihi C, Matu L, ANZALA OA, Kimani J, Embree JE, Plummer FA, Fowke KR. IL-7Ralpha expression on DC4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation. Eur J Immunol. 2006 Feb;. Eur J Immunol. 2006 Feb;36(2):336-44.. : John Benjamins Publishing Company | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/42316 | |
dc.description.abstract | Many factors can influence the rate of HIV disease progression, including those that maintain T cell homeostasis. One key homeostatic regulator is the IL-7 receptor (IL-7R). Previous studies have shown IL-7R expression levels decrease in HIV infection, but effects on memory subtypes, CD4+ T cells, and cell function have not been explored. The present study examined the expression of the IL-7R chain on naïve and memory T lymphocyte subsets of both HIV-positive and HIV-negative individuals from Nairobi, Kenya to assess the role of IL-7R in HIV disease. Expression of IL-7R was significantly reduced in all CD4+ and CD8+ T cell subsets in HIV-positive individuals. This reduction was further enhanced in those with advanced HIV progression. Expression of IL-7R was inversely correlated to immune activation, and apoptosis, and was positively correlated with CD4 count in both bivariate and multivariate analysis. Expression of IL-7R did not correlate with HIV viral loads, indicating the elevated immune activation seen in HIV-infected individuals may be impacting expression of IL-7R, independent of viral loads. Signaling via the IL-7R is essential for T cell homeostasis and maintenance of T cell memory. Reduction of this receptor may contribute to the homeostatic disruption seen in HIV. | |
dc.language.iso | en | en |
dc.publisher | University of nairobi | en |
dc.title | IL-7Ralpha expression on DC4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation | en |
dc.type | Article | en |
local.publisher | College of health science | en |