Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women.
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Date
2007Author
Baeten, JM
McClelland, RS
Wener, MH
Bankson, DD
Lavreys, L
Mandaliya, K
Bwayo, JJ
Kreiss, JK
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Observational studies have suggested that low serum beta-carotene concentrations may influence HIV-1 disease progression. However, randomized trials have not demonstrated beneficial effects of beta-carotene supplementation. To understand this discrepancy, we conducted a cross-sectional study among 400 HIV-1-seropositive women in Mombasa, Kenya, to correlate serum beta-carotene concentrations with several measures of HIV-1 disease severity. beta-Carotene concentrations were significantly associated with biologic markers of HIV-1 disease progression (CD4 count, HIV-1 plasma viral load, serum C-reactive protein [CRP] concentration, and serum albumin level). In multivariate analysis, beta-carotene concentrations below the median were associated with elevated CRP (>10 mg/l, adjusted odds ratio [aOR] 3.32, 95% confidence interval [CI] 1.99-5.53, P<0.001) and higher HIV-1 plasma viral load (for each log(10) copies/mL increase, aOR 1.38, 95% CI 1.01-1.88, P=0.04). In the context of negative findings from randomized trials of beta-carotene supplementation in HIV-1-seropositive individuals, these results suggest that low beta-carotene concentrations primarily reflect more active HIV-1 infection rather than a deficiency amenable to intervention.
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http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/17362556http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/42343
Citation
Baeten JM, McClelland RS, Wener MH, Bankson DD, Lavreys L, Mandaliya K, Bwayo JJ, Kreiss JK; Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women.Publisher
University of Nairobi, College of Health Sciences,
Collections
- Faculty of Health Sciences (FHS) [10377]