dc.contributor.author | Baeten, JM | |
dc.contributor.author | McClelland, RS | |
dc.contributor.author | Wener, MH | |
dc.contributor.author | Bankson, DD | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kreiss, JK | |
dc.date.accessioned | 2013-06-29T10:19:12Z | |
dc.date.available | 2013-06-29T10:19:12Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Baeten JM, McClelland RS, Wener MH, Bankson DD, Lavreys L, Mandaliya K, Bwayo JJ, Kreiss JK; Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women. | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/17362556 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/42343 | |
dc.description.abstract | Observational studies have suggested that low serum beta-carotene concentrations may influence HIV-1 disease progression. However, randomized trials have not demonstrated beneficial effects of beta-carotene supplementation. To understand this discrepancy, we conducted a cross-sectional study among 400 HIV-1-seropositive women in Mombasa, Kenya, to correlate serum beta-carotene concentrations with several measures of HIV-1 disease severity. beta-Carotene concentrations were significantly associated with biologic markers of HIV-1 disease progression (CD4 count, HIV-1 plasma viral load, serum C-reactive protein [CRP] concentration, and serum albumin level). In multivariate analysis, beta-carotene concentrations below the median were associated with elevated CRP (>10 mg/l, adjusted odds ratio [aOR] 3.32, 95% confidence interval [CI] 1.99-5.53, P<0.001) and higher HIV-1 plasma viral load (for each log(10) copies/mL increase, aOR 1.38, 95% CI 1.01-1.88, P=0.04). In the context of negative findings from randomized trials of beta-carotene supplementation in HIV-1-seropositive individuals, these results suggest that low beta-carotene concentrations primarily reflect more active HIV-1 infection rather than a deficiency amenable to intervention. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.title | Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women. | en |
dc.type | Article | en |
local.publisher | College of Health Sciences, | en |