dc.contributor.author | Anderson, AJ | |
dc.contributor.author | Harvey, AL | |
dc.contributor.author | Mbugua, PM | |
dc.date.accessioned | 2013-07-03T14:41:57Z | |
dc.date.available | 2013-07-03T14:41:57Z | |
dc.date.issued | 1985 | |
dc.identifier.citation | Lett. 54: 123.. Federation of Analytical Chemistry and Spectroscopy Society (FACSS) XV, Boston, November 1988. : AWC and FES | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/pmungai/publications/anderson-j-harvey-l-and-mbugua-p-m-1985-effects-fasciculin-2-anticholinesterase | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44842 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/2986055 | |
dc.description.abstract | Fasciculin 2, a polypeptide from green mamba (Dendroaspis angusticeps) venom, causes an increase in the twitch response of mouse phrenic nerve-hemidiaphragm preparations to indirect stimulation. Intracellular recording reveals that fasciculin 2 augments neuromuscular transmission by increasing the amplitude and duration of endplate potentials. Its action is not reversed by washing. Interactions with neostigmine confirm that fasciculin 2 acts as an anticholinesterase. It has no presynaptic actions on transmitter release or postsynaptic receptor blocking actions. On chicken muscle preparations, fasciculin 2 has no anticholinesterase actions. Because of this selectivity and its apparent irreversibility, fasciculin 2 should be useful in characterizing different forms of acetylcholinesterase. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Effects Of Fasciculin 2, An Anticholinesterase Polypeptide From Green Mamba Venom, On Neuromuscular Transmission In Mouse Diaphragm Preparations Neurosci. | en |
dc.type | Article | en |
local.publisher | Faculty of medicine | en |