Spectrum of hemostatic derangements
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Date
2003Author
Pati, HP
Dayal, S
Srivastava, A
Pande, GK
Acharya, KS
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
BACKGROUND: Hemostatic abnormalities have been reported in various hepatocellular diseases. We evaluated the hemostatic functions in patients with Budd-Chiari syndrome. METHODS: Biochemical liver function tests, and measurement of prothrombin time, activated partial thromboplastin time, and plasma levels of anti-thrombin III (antigen) and activity of protein C were done in 36 patients with Budd-Chiari syndrome. RESULTS: Liver biochemistry was abnormal in 34 patients. Plasma prothrombin time and activated partial thromboplastin time were prolonged in 17 (47%) and 23 (64%) patients, respectively. Antithrombin III antigen levels and protein C activity were reduced in 15 (50%) and 25 (83%) patients, respectively, among the 30 patients studied. Albumin levels showed significant correlation with coagulation test results, levels of anti-thrombin-III, and protein C activity. CONCLUSION: Hepatic synthesis of coagulation factors and anticoagulants is reduced in Budd-Chiari syndrome; this may play a role in recurrence of thrombosis.
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http://profiles.uonbi.ac.ke/sacharya/publications/pati-hp-dayal-s-srivastava-pande-gk-acharya-skspectrum-hemostatic-derangementshttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44974
Citation
KIRTDA, DRACHARYAS. 2003. Pati HP, Dayal S, Srivastava A, Pande GK, Acharya SK.Spectrum of hemostatic derangements, in Budd-Chiari syndrome.Indian J Gastroenterol. 2003 Mar-Apr;22(2):59-60.Publisher
Department of Medicine, College of Health Sciences, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]