dc.contributor.author | Pati, HP | |
dc.contributor.author | Dayal, S | |
dc.contributor.author | Srivastava, A | |
dc.contributor.author | Pande, GK | |
dc.contributor.author | Acharya, KS | |
dc.date.accessioned | 2013-07-04T05:58:44Z | |
dc.date.available | 2013-07-04T05:58:44Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | KIRTDA, DRACHARYAS. 2003. Pati HP, Dayal S, Srivastava A, Pande GK, Acharya SK.Spectrum of hemostatic derangements, in Budd-Chiari syndrome.Indian J Gastroenterol. 2003 Mar-Apr;22(2):59-60. | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/sacharya/publications/pati-hp-dayal-s-srivastava-pande-gk-acharya-skspectrum-hemostatic-derangements | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44974 | |
dc.description.abstract | BACKGROUND: Hemostatic abnormalities have been reported in various hepatocellular diseases. We evaluated the hemostatic functions in patients with Budd-Chiari syndrome. METHODS: Biochemical liver function tests, and measurement of prothrombin time, activated partial thromboplastin time, and plasma levels of anti-thrombin III (antigen) and activity of protein C were done in 36 patients with Budd-Chiari syndrome. RESULTS: Liver biochemistry was abnormal in 34 patients. Plasma prothrombin time and activated partial thromboplastin time were prolonged in 17 (47%) and 23 (64%) patients, respectively. Antithrombin III antigen levels and protein C activity were reduced in 15 (50%) and 25 (83%) patients, respectively, among the 30 patients studied. Albumin levels showed significant correlation with coagulation test results, levels of anti-thrombin-III, and protein C activity. CONCLUSION: Hepatic synthesis of coagulation factors and anticoagulants is reduced in Budd-Chiari syndrome; this may play a role in recurrence of thrombosis. | en |
dc.language.iso | en | en |
dc.title | Spectrum of hemostatic derangements | en |
dc.type | Article | en |
local.publisher | Department of Medicine, College of Health Sciences, University of Nairobi | en |