Anti-pre-S antibodies in different groups of patients with hepatitis B virus infection
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Date
1989Author
Irshad, M
Gandhi, BM
Acharya, KS
Joshi, YK
Tandon, BN
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The anti-pre-S antibody in the samples of sera from normal healthy persons and patients with different clinical types of liver diseases due to hepatitis B virus (HBV) infection was detected by a newly established enzyme-linked immunosorbent assay technique. This test is a blocking assay where anti-pre-S antibody in the patient's serum blocks subsequent addition of horse radish peroxidase-labelled polymerized human serum albumin (pHSA) to the pHSA-receptor site of HBsAg molecules fixed on a solid surface. Anti-pre-S activity was not detected in any from 95 healthy persons who were negative for all HBV-markers or from 105 healthy HBV carriers. In 12 sera from HBV vaccine recipients, anti-pre-S activity was noted in higher proportions compared with anti-HBs, after both the second and third doses of vaccine. Anti-pre-S activity was detected in small proportions of HBsAg positive sera from acute viral hepatitis (4.2%) and chronic active hepatitis (10%). In subacute viral hepatitis patients, the anti-pre-S antibody was totally absent. However, anti-pre-S activity was recorded in high proportions of HBsAg-positive sera from patients with cirrhosis of liver (57.2%) and fulminant hepatitis (41.6%). The anti-pre-S antibodies were assumed to be implicated in the clearance of HBV particles from circulation without causing tissue damage.
URI
http://profiles.uonbi.ac.ke/sacharya/publications/irshad-m-gandhi-bm-acharya-sk-joshi-yk-tandon-bnanti-pre-s-antibodies-differenhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/46511
Citation
KIRTDA, DRACHARYAS. 1989. Irshad M, Gandhi BM, Acharya SK, Joshi YK, Tandon BN.Anti-pre-S antibodies in different groups of patients with hepatitis B virus infection.J Gastroenterol Hepatol. 1989 Jan-Feb;4(1):25-32.Publisher
Department of Medicine, College of Health Sciences, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10377]