dc.contributor.author | Irshad, M | |
dc.contributor.author | Gandhi, BM | |
dc.contributor.author | Acharya, KS | |
dc.contributor.author | Joshi, YK | |
dc.contributor.author | Tandon, BN | |
dc.date.accessioned | 2013-07-08T12:50:40Z | |
dc.date.available | 2013-07-08T12:50:40Z | |
dc.date.issued | 1989 | |
dc.identifier.citation | KIRTDA, DRACHARYAS. 1989. Irshad M, Gandhi BM, Acharya SK, Joshi YK, Tandon BN.Anti-pre-S antibodies in different groups of patients with hepatitis B virus infection.J Gastroenterol Hepatol. 1989 Jan-Feb;4(1):25-32. | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/sacharya/publications/irshad-m-gandhi-bm-acharya-sk-joshi-yk-tandon-bnanti-pre-s-antibodies-differen | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/46511 | |
dc.description.abstract | The anti-pre-S antibody in the samples of sera from normal healthy persons and patients with different clinical types of liver diseases due to hepatitis B virus (HBV) infection was detected by a newly established enzyme-linked immunosorbent assay technique. This test is a blocking assay where anti-pre-S antibody in the patient's serum blocks subsequent addition of horse radish peroxidase-labelled polymerized human serum albumin (pHSA) to the pHSA-receptor site of HBsAg molecules fixed on a solid surface. Anti-pre-S activity was not detected in any from 95 healthy persons who were negative for all HBV-markers or from 105 healthy HBV carriers. In 12 sera from HBV vaccine recipients, anti-pre-S activity was noted in higher proportions compared with anti-HBs, after both the second and third doses of vaccine. Anti-pre-S activity was detected in small proportions of HBsAg positive sera from acute viral hepatitis (4.2%) and chronic active hepatitis (10%). In subacute viral hepatitis patients, the anti-pre-S antibody was totally absent. However, anti-pre-S activity was recorded in high proportions of HBsAg-positive sera from patients with cirrhosis of liver (57.2%) and fulminant hepatitis (41.6%). The anti-pre-S antibodies were assumed to be implicated in the clearance of HBV particles from circulation without causing tissue damage. | en |
dc.language.iso | en | en |
dc.title | Anti-pre-S antibodies in different groups of patients with hepatitis B virus infection | en |
dc.type | Article | en |
local.publisher | Department of Medicine, College of Health Sciences, University of Nairobi | en |