dc.contributor.author | Murray, PG | |
dc.contributor.author | Woodman, CB | |
dc.contributor.author | Stankovic, T | |
dc.contributor.author | Teo, SH | |
dc.contributor.author | Young, LS | |
dc.contributor.author | Lim, PV | |
dc.contributor.author | Arrand, J | |
dc.contributor.author | Wei, W | |
dc.contributor.author | Buettner, M | |
dc.contributor.author | Maina, E | |
dc.contributor.author | Chukwuma, MB | |
dc.contributor.author | Dawson, C | |
dc.contributor.author | Morgan, S | |
dc.contributor.author | Saleh, A | |
dc.contributor.author | Starzcynski, J | |
dc.contributor.author | Fung, M | |
dc.contributor.author | Yap, LF | |
dc.contributor.author | Bose, S | |
dc.date.accessioned | 2013-07-17T09:57:16Z | |
dc.date.available | 2013-07-17T09:57:16Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | J Pathol. 2009 Feb;217(3):345-52. doi: 10.1002/path.2487. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19142888 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/48483 | |
dc.description.abstract | A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease. | en |
dc.language.iso | en | en |
dc.title | The ATM Tumour Suppressor Gene Is Down-regulated In EBV-associated Nasopharyngeal Carcinoma. | en |
dc.type | Article | en |
local.publisher | Department of Biochemistry | en |