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Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin

dc.contributor.authorProdger, JL
dc.contributor.authorGray, R
dc.contributor.authorKigozi, G
dc.contributor.authorNalugoda, F
dc.contributor.authorGaliwango, R,
dc.contributor.authorNehemiah, K
dc.contributor.authorKakanga, M
dc.contributor.authorHirbod, T
dc.contributor.authorWawer, MJ
dc.contributor.authorSewankambo, N
dc.contributor.authorSerwadda, D
dc.contributor.authorKaul, R
dc.contributor.authorRakai Genital Immunology Research Group.
dc.date.accessioned2013-12-03T10:12:09Z
dc.date.available2013-12-03T10:12:09Z
dc.date.issued2012-06
dc.identifier.citationAIDS. 2012 Jun 19;26(10):1319-22. doi: 10.1097/QAD.0b013e328354675c.en
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/22516874
dc.identifier.urihttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/61625
dc.description.abstractHerpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.en
dc.language.isoenen
dc.publisherUniversity of Nairobien
dc.titleImpact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskinen
dc.typeArticleen
local.publisherDepartment of Medicineen


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