Renal manifestations in children with sickle cell anemia
Abstract
Twenty one children admitted to the Kenyatta National
Hospital with sickle cell anaemia were studied with the aim
of detecting the renal defects associated with this haemogloblnopathy.
In a controlled study investigation was limited to simple,
non-invasiva techniques which included urine analysis and
culture, determination of creatinine clearance and urine flow
rate, and a urine concentration test.
Patients in sickle cell crisis were shown to have a reduced
GFR and urine flow rate. A urine concentration impairment
which has been shown in other studies was confirmed. Further
study on gYaonephri tis in sickle cell disease was recommended