Chemotherapy of malaria with special reference to drug interactions with chloroquine and herbal management of malaria in Kenya
Abstract
The first part of this project deals with
chloroquine and its interactions with other drugs.
A survey carried out in New Nyanza General Hospital
(Kisumu, Kenya) a malaria endemic area, revealed that
chloroquine was indeed the first line of management in
the chemotherapy of malaria. The same survey indicated
that chloroquine poisoning contributed to a total of
429 deaths in the above hospital within a span of
seven years.
Out of a sample of 1,153 patients treated in the
outpatient clinic during-the survey period showed that
65.9% were adults. No sex variation in the treatment
and incidence of malaria was noticed.
Chloroquine dosage varied from an underdose of 6 by
250mg tablets in 3 days to an overdose of 20 by 250mg
tablet in 5 days. Out of the analysed population 3.4%
was given prophylactic treatment with a dose of 2 by
250mg chloroquine tablets weekly for a period ranging
from 10 weeks to 6 months.
Chloroquine drug combination therapy showed that
the highest frequency was with aspirin at 23.12%
followed by paracetamol with a frequency of 18.85%.
This reveals that analgesic antipyretics are routinely
given with chloroquine.
Citation
Degree Of Doctor Of Philosophy,Department of Pharmacy College of Health Sciences, University Of Nairobi, 1990Publisher
University of Nairobi
Description
A Thesis Submitted In Fulfilment For The Degree Of Doctor Of Philosophy In The University Of Nairobi