| dc.contributor.author | Guantai, A N | |
| dc.date.accessioned | 2014-06-23T06:28:17Z | |
| dc.date.available | 2014-06-23T06:28:17Z | |
| dc.date.issued | 1990 | |
| dc.identifier.citation | Degree Of Doctor Of Philosophy,Department of Pharmacy College of Health Sciences, University Of Nairobi, 1990 | en_US |
| dc.identifier.uri | http://hdl.handle.net/11295/70429 | |
| dc.description | A Thesis Submitted In Fulfilment For The Degree Of Doctor Of Philosophy In The University Of Nairobi | en_US |
| dc.description.abstract | The first part of this project deals with
chloroquine and its interactions with other drugs.
A survey carried out in New Nyanza General Hospital
(Kisumu, Kenya) a malaria endemic area, revealed that
chloroquine was indeed the first line of management in
the chemotherapy of malaria. The same survey indicated
that chloroquine poisoning contributed to a total of
429 deaths in the above hospital within a span of
seven years.
Out of a sample of 1,153 patients treated in the
outpatient clinic during-the survey period showed that
65.9% were adults. No sex variation in the treatment
and incidence of malaria was noticed.
Chloroquine dosage varied from an underdose of 6 by
250mg tablets in 3 days to an overdose of 20 by 250mg
tablet in 5 days. Out of the analysed population 3.4%
was given prophylactic treatment with a dose of 2 by
250mg chloroquine tablets weekly for a period ranging
from 10 weeks to 6 months.
Chloroquine drug combination therapy showed that
the highest frequency was with aspirin at 23.12%
followed by paracetamol with a frequency of 18.85%.
This reveals that analgesic antipyretics are routinely
given with chloroquine. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.title | Chemotherapy of malaria with special reference to drug interactions with chloroquine and herbal management of malaria in Kenya | en_US |
| dc.type | Thesis | en_US |
| dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
