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Repeat use of post exposure prophylaxis for HIV among Nairobi based female sex workers following sexual exposure
(University of Nairobi, 2015-05-13)
As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis ...
Preventing HIV-1 Infection, More Epitope Is Not Better: Analysis of Gag Epitope of 2 HLA Alleles Associated with Different Outcome of HIV Infection
(2012)
Background: Current HIV vaccine candidates have been based on
the conventional views of viral infection and attempt to induce
broad T cell responses to HIV-1. Until now, the candidate vaccines
based on such approach ...
Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV Exposed, seronegative female sex workers in Kenya
(2012)
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune ...
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol
(2009)
Background
The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...
A Genetic Polymorphism of FREM1 Is Associated with Resistance against HIV Infection in the Pumwani Sex Worker Cohort
(2012)
A subgroup of women enrolled in the Pumwani sex worker cohort remain seronegative and PCR negative for human immunodeficiency virus type 1 despite repeated exposure through high-risk sex work. Studies have shown that ...
Does antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case–control study
(2012)
Although antiretroviral therapy (ART) prolongs life and reduces infectiousness, in some contexts, it has been associated with increased sexual risk taking.
Design
Retrospective case–control study.
Setting
...
Screening for HIV-specific T-cell responses using overlapping 15-mer peptide pools or optimized epitopes
(Univesity of Nairobi, 2004)
The IFN-ª enzyme-linked immunospot (ELISpot)
assay is often used to map HIV-specific
CD8 T-cell responses. We compared overlapping
15-mer pools with optimized CD8 epitopes to
screen ELISpot responses in HIV-infected ...
Donating Human Samples: Who Benefits? Cases from Iceland, Kenya and Indonesia
(University of Nairobi, 2013-01)
Benefit sharing involving human genetic resources is an unresolved topic. Some argue that participation in scientific research should always be altruistically motivated, which is how access to human genetic resources has ...
Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi, Kenya
(2013-10-22)
Aging of the immune system, known as immunosenescence, is associated with profound changes in both innate and adaptive immune responses, resulting in increased susceptibility to infection and a decreased ability to respond ...
Naturally occurring protease inhibitor resistance mutations and their frequencies in HIV proviral sequences of drug-naïve sex workers in Nairobi, Kenya
(University of Nairobi, 2014-01-07)
Sub-Saharan Africa accounts for 69% of the people living with HIV globally. An estimated 1,600,000 Kenyans are living with HIV-1. Antiretroviral therapy (ART) has saved 9 million life-years in Sub-Saharan Africa. However, ...