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Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract
(University of Nairobi, 2014-12)
Problem
The expression of inhibitory markers such as LAG-3 and PD-1 on T lymphocytes regulates immune function. Their expression at the genital mucosa is poorly understood, but regulation of immune activation at the ...
Multiplex detection of bacteria associated with normal microbiota and with bacterial vaginosis in vaginal swabs by use of oligonucleotide-coupled fluorescent microspheres
(2009)
Bacterial vaginosis (BV) is a recurrent condition that is associated with a range of negative outcomes,
including the acquisition of human immunodeficiency virus and other sexually transmitted diseases,
preterm births, ...
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
(2012)
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in
particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective ...
Cervical HIV-specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV
(2009)
We conducted a comprehensive cross-sectional analysis of total and HIV-specific cervical antibody levels in HIV-
1-resistant, uninfected, and infected women in order to examine the role of HIV-specific antibody responses ...
For protection from HIV-1 infection, more might not be better: a systematic analysis of HIV Gag epitopes of two alleles associated with different outcomes of HIV-1 infection
(Univerisyt of Nairobi, 2011)
A subset of women in the Pumwani Sexworker cohort, established in 1985 in Nairobi, Kenya, remains uninfected despite repeated high-risk exposure(HESN) through active sex work. This HESN phenotype is associated with several ...
The role of G Protein Gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
(2012-01-03)
Abstract
Background
The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to ...
HIV viral set point and host immune control in individuals with HIV-specific CD8R T-cell responses prior to HIV acquisition
(2010)
OBJECTIVE:
Vaccine-induced CD8(+) T-cell responses in primates have been associated with a reduced simian immunodeficiency virus plasma viral load and enhanced T-cell responses, but cellular vaccines have shown limited ...
The origins of a research community in the Majengo observational cohort study, Nairobi, Kenya
(2010)
Background
Since the 1980s the Majengo Observational Cohort Study (MOCS) has examined sexually transmitted infections, in particular HIV/AIDS, in a cohort of sex workers in Majengo, an impoverished urban village in ...
Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses
(University of Nairobi, 2001-02-01)
Resistance to HIV infection in a small group of Kenyan sex workers is associated with CD8+-lymphocyte responses to HIV cytotoxic T-lymphocyte (CTL) epitopes. Eleven prostitutes meeting criteria for HIV resistance seroconverted ...