HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
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Date
2012Author
McKinnon, Lyle R.
Nagelkerke, Nico J.
Kaul, Rupert
Shaw, Souradet Y.
Capina, Rupert
Luo, Ma
Kariri, Anthony
Apidi, Winnie
Kimani, Makobu
Wachihi, Charles
Jaoko Walter G.
Anzala Aggrey O.
Kimani, Joshua
Ball, T. Blake
Plummer, Francis A.
Type
ArticleLanguage
enMetadata
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HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in
particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker
cohort (1985–2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4%
decline per year, 1.53-fold increase, p = 0.015). This was independent of ‘‘protective’’ HLA and country of origin (p = 0.053),
which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data
confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and
requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while
controlling for protective HLA alleles.
URI
http://www.ncbi.nlm.nih.gov/pubmed/23185441http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9926
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504142/
Citation
PLoS ONE 7(11): e49797.Collections
- Faculty of Health Sciences (FHS) [10377]