HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
dc.contributor.author | McKinnon, Lyle R. | |
dc.contributor.author | Nagelkerke, Nico J. | |
dc.contributor.author | Kaul, Rupert | |
dc.contributor.author | Shaw, Souradet Y. | |
dc.contributor.author | Capina, Rupert | |
dc.contributor.author | Luo, Ma | |
dc.contributor.author | Kariri, Anthony | |
dc.contributor.author | Apidi, Winnie | |
dc.contributor.author | Kimani, Makobu | |
dc.contributor.author | Wachihi, Charles | |
dc.contributor.author | Jaoko Walter G. | |
dc.contributor.author | Anzala Aggrey O. | |
dc.contributor.author | Kimani, Joshua | |
dc.contributor.author | Ball, T. Blake | |
dc.contributor.author | Plummer, Francis A. | |
dc.date.accessioned | 2013-02-14T15:13:43Z | |
dc.date.available | 2013-02-14T15:13:43Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | PLoS ONE 7(11): e49797. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23185441 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9926 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504142/ | |
dc.description.abstract | HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985–2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of ‘‘protective’’ HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles. | en |
dc.language.iso | en | en |
dc.subject | HIV-1 Clade D | en |
dc.subject | CD4 | en |
dc.subject | Sex worker | en |
dc.title | HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort | en |
dc.type | Article | en |
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