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Now showing items 41-50 of 96
Safety of a nonoxynol-9 vaginal gel in Kenyan prostitutes. A randomized clinical trial
(University of Nairobi, 1997-05)
OBJECTIVE:
To evaluate the safety and toxicity of once-daily administration of Advantage-24 (Columbia Research Laboratories, Inc., Rockville Centre, NY), a vaginal gel containing 52.5 mg of nonoxynol-9 (N-9), including ...
Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina.
(University of Nairobi, 1997-09)
BACKGROUND: Factors that influence shedding of HIV-1 infected cells in cervical and vaginal secretions may be important determinants of sexual and vertical transmission of the virus. We investigated whether hormonal ...
The role of cytotoxic T-cells in HIV infection
(University of Nairobi, 1998)
HIV-specific cytotoxic T lymphocytes (CTL) are believed to play a major role in controlling virus levels through the asymptomatic period of HIV infection. For the rational design of an HIV vaccine, we need to know whether ...
Mother-child class I HLA concordance increases perinatal human immunodeficiency virus type 1 transmission
(University of Nairobi, 1998-03)
Major histocompatibility complex (MHC) gene products are expressed on human immunodeficiency virus (HIV)-infected cells and incorporated into the lipid envelope of HIV virions. Macaques immunized with human MHC gene products ...
Clinical and in situ cellular responses to Haemophilus ducreyi in the presence or absence of HIV infection.
(1998)
We aimed to determine if the clinical and histological features of chancroid are altered by HIV infection. Male patients presenting to the Nairobi special treatment clinic with a clinical diagnosis of chancroid were eligible ...
Association between cervical inflammation and cervical shedding of human immunodeficiency virus DNA
(University of Nairobi, 1994-12)
A cross-sectional study was conducted among prostitutes in Nairobi, Kenya, to determine the prevalence and correlates of cervical human immunodeficiency virus (HIV) DNA. Ninety-two HIV-seropositive prostitutes were evaluated ...
Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes
(University of Nairobi, 1992)
OBJECTIVE–To determine the efficacy of the nonoxynol 9 contraceptive sponge in preventing sexual acquisition of the human immunodeficiency virus (HIV). DESIGN–Prospective, randomized placebo-controlled trial. SETTING–Research ...
Presumptive specific clinical diagnosis of genital ulcer disease (GUD) in a primary health care setting in Nairobi
(University of Nairobi, 1996)
Of 22,274 patients 12 years of age or older attending a primary health care clinic in Nairobi, 1076 (4.8%) complained of symptoms suggesting a sexually transmitted disease (STD). Of these, 518 females and 462 males underwent ...
Morphological Study of Penile Chancroid Lesions in Human Immunodeficiency Virus(HIV)
(University of Nairobi, 1996-10)
Chancroid, the most common cause of genital ulceration in Africa, is known to be associated epidemiologically with heterosexual transmission of human immunodeficiency virus (HIV). The pathophysiological mechanisms by which ...
Cervical Shedding Of Cytomegalovirus In Human Immunodeficiency Virus Type 1-infected Women.
(University of Nairobi, 1999)
Cervical shedding of cytomegalovirus (CMV) is important in transmission of CMV to exposed sexual partners and neonates. We evaluated prevalence and correlates of CMV DNA shedding in cervical secretions from a large cohort ...