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Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis
(2012)
Although bacterial vaginosis is a known correlate of HIV infection, no previous studies have investigated whether women defined as HIV-exposed seronegative (HESN) are less likely to have bacterial vaginosis. Little is known ...
CD26/ dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected Female sex workers
(2010-11-25)
Abstract
Background
Design of effective vaccines against the human immunodeficiency virus (HIV-1) continues to present formidable challenges. However, individuals who are exposed HIV-1 but do not get infected may reveal ...
Effect of Baseline HIV Disease Parameters on CD4+ T Cell Recovery After Antiretroviral Therapy Initiation in Kenyan Women
(2010)
Background
Antiretroviral therapy (ART) for HIV infection reconstitutes the immune system and improves survival. However, the rate and extent of CD4+ T cell recovery varies widely. We assessed the impact of several ...
HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
(2010)
Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine
design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce
lower ...
Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T Cell responses in the cervix
(2010)
Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the
initial site of HIV acquisition. However, standardized and sensitive methods for evaluating ...
Preventing HIV-1 Infection, More Epitope Is Not Better: Analysis of Gag Epitope of 2 HLA Alleles Associated with Different Outcome of HIV Infection
(2012)
Background: Current HIV vaccine candidates have been based on
the conventional views of viral infection and attempt to induce
broad T cell responses to HIV-1. Until now, the candidate vaccines
based on such approach ...
Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV Exposed, seronegative female sex workers in Kenya
(2012)
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune ...
A Genetic Polymorphism of FREM1 Is Associated with Resistance against HIV Infection in the Pumwani Sex Worker Cohort
(2012)
A subgroup of women enrolled in the Pumwani sex worker cohort remain seronegative and PCR negative for human immunodeficiency virus type 1 despite repeated exposure through high-risk sex work. Studies have shown that ...
Does antiretroviral therapy initiation increase sexual risk taking in Kenyan female sex workers? A retrospective case–control study
(2012)
Although antiretroviral therapy (ART) prolongs life and reduces infectiousness, in some contexts, it has been associated with increased sexual risk taking.
Design
Retrospective case–control study.
Setting
...
Blunted IL17/IL22 and Pro-Inflammatory Cytokine Responses in the Genital Tract and Blood of HIV-Exposed, Seronegative Female Sex Workers in Kenya
(University of Nairobi, 2012)
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune ...