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Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.
(University of Nairobi, 2015)
OBJECTIVE:
Cationic proteins found in cervicovaginal secretions (CVS) are known to contribute to the early antiviral immune response against HIV-infection in vitro. We here aimed to define additional antiviral factors ...
Associations Of Human Leukocyte Antigen-g With Resistance And Susceptibility To Hiv-1 Infection In The Pumwani Sex Worker Cohort.
(University of Nairobi, 2013-01)
OBJECTIVE:
To determine the association between human leukocyte antigens (HLA)-G genotypes and resistance or susceptibility to HIV-1.
DESIGN:
A group of sex workers in Pumwani, Kenya can be epidemiologically defined ...
Altered Dendritic Cell-natural Killer Interaction In Kenyan Sex Workers Resistant To Hiv-1 Infection.
(University of Nairobi, 2012-02)
BACKGROUND:
Natural killer (NK) cells are members of the innate immune system that play an important role in the defense against viral infection. They are also involved in the regulation of adaptive immune responses ...
Human Interferon Regulatory Factor-1 Gene And Its Promoter Sequences Revealed By Population-based Complete Gene Sequencing.
(University of Nairobi, 2008-06)
Interferon regulatory factor-1 (IRF-1) plays important roles in host immunity, cell proliferation and apoptosis. The current GenBank sequence for human IRF-1 (accession number: L05072) was derived from a human placenta DNA ...
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
(University of Nairobi, 2009-09)
BACKGROUND:
The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...
Stable CD4 Expression and Local Immune Activation in the Ectocervical Mucosa of HIV-Infected Women.
(2013)
Studies using genital tissue samples from HIV-infected women might provide important information about HIV susceptibility and transmission. In this study, ectocervical biopsies were obtained from 20 HIV-seropositive (HIV(+)) ...
Epigenetic Control Of Irf1 Responses In HIV-exposed Seronegative Versus HIV-susceptible Individuals.
(University of Nairobi, 2011-03)
Not all individuals exposed to HIV become infected. Understanding why these HIV-exposed seronegative individuals remain uninfected will help inform the development of preventative measures against HIV infection. Interferon ...
Cross-clade CD8(+) T-cell responses with a preference for the predominant circulating clade
(University of Nairobi, 2005-11)
Human immunodeficiency virus (HIV) genetic diversity is a major impediment to the design of a successful vaccine. Even if an HIV vaccine is proven effective, it remains to be seen whether this protection will extend to ...
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.
(2010)
BACKGROUND:
Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ...
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
(University of Nairobi,, 2009-09)
BACKGROUND:
The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...