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Infant Safety during and after Maternal Valacyclovir Therapy in Conjunction with Antiretroviral HIV-1 Prophylaxis in a Randomized Clinical Trial
(2012)
Background
Maternal administration of the acyclovir prodrug valacyclovir is compatible with pregnancy and breastfeeding. However, the safety profile of prolonged infant and maternal exposure to acyclovir in the context ...
Effects of Valcyclovir on markers of disease Progression in Postpartum Women Co-Infected with HIV-1 andHerpes Simplex Virus-2
(2012-06)
Objective:
Herpes simplex virus type 2 (HSV-2) suppression has been shown to reduce HIV-1 disease progression in nonpregnant
women and men, but effects on pregnant and postpartum women have not been described.
Methods:
We ...
Rapid Decline in Risk of HIV-l Acquisition After Enrollment in a Vaccine Preparedness Cohort of Kenyan Prostitutes: Implications for the Design of HIV -1 Vaccine Efficacy Trials
(2002-02)
Background: In designing HIY-l vaccine efficacy trials, it will be important to accounrfor changes in HIY -1 incidence, especially changes over time and while participating in riskreduction programs.
Methods: Data from ...
Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET012 nevirapine versus short-course zidovudine
(2005)
Objective: To compare the effect of perinatal regimens of short-course nevirapine
(HIVNET012)andzidovudine[Thai-CentersforDiseaseControlandPrevention(CDC)
regimen] on breast milk viral shedding and perinatal transmission ...
Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women
(2007)
Objective
To assess the immediate and longer-term effects of the use of hormonal contraception on the progression of HIV-1 disease in postpartum women.
Design
A prospective cohort study.
Methods
Information on ...
Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure
(2011)
BACKGROUND:
Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in ...
New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workers
(2001)
A clearer understanding of HIV-1 specific immune responses in highly-exposed, persistently seronegative (HEPS) subjects is important in developing models of HIV-1 protective immunity. HIV-1 specific cytotoxic T-lymphocytes ...
Highly Active Antiretroviral Therapy (HAART) versus Zidovudine/Nevirapine Effects on Early Breast Milk HIV-1 RNA: A Phase II Randomized Clinical Trial
(2008)
Background
Defining the effect of antiretroviral regimens on breast milk HIV-1 levels is useful to inform the rational design of strategies to decrease perinatal HIV-1 transmission.
Methods
Pregnant HIV-1 seropositive ...
Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting
(2011)
Background
The aim of this study was to develop an economical 'in-house' single round polymerase chain reaction (PCR) assay using filter paper-dried blood spots (FP-DBS) for early infant HIV-1 diagnosis and to evaluate ...
Predicted HIV-1 coreceptor usage among Kenya patients shows a high tendency for subtype d to be cxcr4 tropic
(2012)
Background: CCR5 antagonists have clinically been approved for prevention or treatment of HIV/AIDS. Countries in
Sub-Saharan Africa with the highest burden of HIV/AIDS are due to adopt these regimens. However, HIV-1 can ...