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Antiplasmodial and cytotoxic activities of the constituents of turraea robusta and turraea nilotica
(University of Nairobi, 2015-08)
Ethnopharmacological relevance
Turraea robusta and Turraea nilotica are African medicinal plants used for the treatment of a wide variety of diseases, including malaria. The genus Turraea is rich in limonoids and other ...
3-Oxo-14α,15α-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides
(University of Nairobi, 2014-07)
The stem bark extract of the Schizozygia coffaeoides (Apocynaceae) showed moderate antiplasmodial activity (IC50 = 8–12 μg/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium ...
Antiplasmodial, cytotoxicity and phytochemical constituents of four maytenus species used in traditional medicine in Kenya
(2017)
Background: In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. ...
8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica
(2009)
A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the
root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and
shinpterocarpin ...
(+)-Tephrodin - A New Flavone from Tephrosia purpurea
(1972)
Tephrosia species are widely used
in East African traditional medicinal
practice to treat various infectious
diseases. In our continued search
for antiplasmodial agents from
Tephrosia species found in Kenya a
new ...
Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea
(Elsevier B.V., 2011)
The stem extract of Tephrosia purpurea showed anti plasmodial activity against the D6 (chloroquinesensitive)
and W2 (chloroquine-resistant) strains of Plasmodium /aldparum with 1(50 values of
10.47 ± 2.22 f.Lg/mland 12.06 ...
Two new flavonoids from Dracaena usambarensis Engl.
(University of Nairobi, 2020)
Investigations of the root extract of Dracaena usambarensis Engl. for anticancer principles led to the characterization of one new homoisoflavonoid, (3S)-3,4ʹ,5,6-tetrahydroxy-7-methoxyhomoisoflavanone (1) and a new ...
Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.
(University of Nairobi, 2019)
Introduction: Plants of the genus Garcinia are traditionally used treat a
range of infectious and non-infectious diseases. Garcinia species are
reported to have been shown to have a range of biological activities
including ...
Cytotoxicity Of Isoflavones And Biflavonoids From Ormocarpum Kirkii Towards Multi-factorial Drug Resistant Cancer
(University of Nairobi, 2019)
Background
While incidences of cancer are continuously increasing, drug resistance of malignant cells is observed towards almost all pharmaceuticals. Several isoflavonoids and flavonoids are known for their cytotoxicity ...
Two novel lignans derivatives and two fusicoccane diterpenoids from whole plant of Hypoestes verticillaris (L.f.) Sol. ex Roem. & Schult
(University of Nairobi, 2019)
Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2:MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydrohel ...