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    Prognostic relevance of integrated genetic profiling in acute myeloid leukemia 

    Huberman, K; Aminova, O; Thomas, S; Dolgalev, L; Van Vlierberghe, P; Racevskis, J; Sun, Z; Fernandez, H; Figueroa, ME; Gönen, M; Patel, JP; Cheng, J; van den Brink, MR; Litzow, M; Gallagher, RE; Ketterling, RP; Viale, A; Socci, ND; Heguy, A; Cherry, A; Vance, G; Higgins, RR; Levine, RL; Abdel-Wahab, O; Melnick, A; Tallman, MS; Paietta, E; Ferrando, A; Luger, S; Rowe, JM; Lazarus, HM (2012)
    BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated ...
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    Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis 

    Diab, A; Zickl, L; Abdel-Wahab, O; Jhanwar, S; Gulam, MA; Panageas, KS; Patel, JP; Jurcic, J; Maslak, P; Paietta, E; Mangan, JK; Carroll, M; Fernandez, HF; Teruya-Feldstein, J; Luger, SM; Douer, D; Litzow, MR,; Lazarus, HM; Rowe, JM; Levine, RL; Tallman, MS (2013)
    Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, ...
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    How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia? 

    Patel, JP; Levine, RL (2012)
    Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease ...
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    ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression 

    Levine, RL; Bernstein, BE; Aifantis, I; Jaffe, JD; Nimer, SD; Melnick, A; Carroll, M; Abdel-Wahab, O; Park, CY; Taylor, JE; Zhao, X; Perna, F; Koche, R; Chung, YR; Patel, JP; Pandey, S; Shih, AH; Hricik, T; Gao, J; LaFave, LM; Adli, M (2012)
    Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ...
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    Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia 

    Meyer, JA; Wang, J; Hogan, LE; Yang, JJ; Dandekar, S; Patel, JP; Tang, Z; Zumbo, P; Li, S; Zavadil, J; Levine, RL; Cardozo, T; Hunger, SP; Raetz, EA; Evans, WE; Morrison, DJ; Mason, CE; Carroll, WL (2013)
    Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...
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    Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis 

    Levine, RL; Abdel-Wahab, O; Brennan, CW; Godley, LA; Melnick, A; Mason, CE; Gonen, M; Bhatt, PK; Socci, N; Hassimi, M; Heguy, A; Viale, A; Li, J; Mollica, L; Hamilou, Z; Provost, S; Vasanthakumar, A; Busque, L; Patel, JP; Figueroa, ME (2012)
    Abstract Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated ...
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    Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies 

    Oyer, JA; Huang, X; Zheng, Y; Shim, J; Ezponda, T; Carpenter, Z; Allegretta, M; Okot-Kotber, CI; Patel, JP; Melnick, A; Levine, RL; Mackerell, AD; Kelleher, NL; Licht, JD; Popovic, R (2013)
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    Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia 

    DiNardo, CD; Propert, KJ; Loren, AW; Paietta, E; Sun, Z; Levine, RL; Straley, KS; Yen, K; Patel, JP; Agresta, S; Abdel-Wahab, O; Perl, AE; Litzow, MR; Rowe, JM; Lazarus, HM; Fernandez, HF; Margolis, DJ; Tallman, MS; Luger, SM; Carroll, M (2013)
    Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...
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    CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900 

    Gönen, M; Sun, Z; Figueroa, ME; Patel, JP; Abdel-Wahab, O; Racevskis, J; Ketterling, RP; Fernandez, H; Rowe, JM; Tallman, MS; Melnick, A; Levine, RL; Paietta, E (2012)
    We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ...
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    The role of mutations in epigenetic regulators in myeloid malignancies 

    Shih, AH; Abdel-Wahab, O; Patel, JP; Levine, RL (2012)
    The role of mutations in epigenetic regulators in myeloid malignancies. Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative ...

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    Levine, RL (10)
    Patel, JP (10)
    Abdel-Wahab, O (7)Melnick, A (5)Paietta, E (4)Rowe, JM (4)Tallman, MS (4)Carroll, M (3)Figueroa, ME (3)Lazarus, HM (3)... View MoreDate Issued2012 (6)2013 (4)Has File(s)Yes (9)No (1)

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