Browsing Faculty of Health Sciences (FHS) by Title
Now showing items 6063-6082 of 10387
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Molecular Characterization of HIV Type 1 Among HIV-Infected Respondents in a Cohort Being Prepared for HIV Phase III Vaccine Clinical Trials, Western Kenya
(Kenyatta University, Department of Biological Sciences, Nairobi, KenyaKenya Aids Vaccine Initiative (KAVI), Department of Medical Microbiology, University of NairobiDivision of Medical Virology, National Health Laboratory Services (NHLS) and University of Stellenbosch, Tygerberg, South Africa, 2011)Kenya is one of the sub-Saharan African countries affected by HIV-1 infection and AIDS. We investigated HIV-1 genetic diversity in 130 individuals from Busia, Bungoma, and Kakamega in western Kenya as part of an HIV-1 ... -
Molecular characterization of human coronavirus circulating in Kenya, 2009-2012
(University of Nairobi, 2014)Background: The genome of a human coronavirus (HCoV) is composed of a linear, single-stranded, non-segmented, positive-sense RNA of 27-32 kb. The pol gene of HCoV found in ORF1ab, is a good molecular chronometer for molecular ... -
Molecular characterization of human coronaviruses and their circulation dynamics in Kenya, 2009-2012.
(University of Nairobi, 2016)Background Human Coronaviruses (HCoV) are a common cause of respiratory illnesses and are responsible for considerable morbidity and hospitalization across all age groups especially in individuals with compromised ... -
Molecular characterization of human parainfluenza virus type 1 in infants attending Mbagathi district hospital, Nairobi, Kenya: a retrospective study
(University of Nairobi, 2013-12)Human parainfluenza virus type 1 (HPIV-1), a paramyxovirus, is a leading cause of pediatric respiratory hospitalizations globally. Currently, there is no clinically successful vaccine against HPIV-1. Hence, there is a need ... -
Molecular characterization of Theileria parasites: application to the epidemiology of theileriosis in Zimbabwe.
(Univesity of NairobiDepartment of Medicine, 1994-12)Forty Theileria schizont-infected lymphocyte culture isolates from Zimbabwe were characterized using a panel of antischizont monoclonal antibodies (MAbs) and 4 Theileria parva DNA probes containing cloned extrachromosomal ... -
Molecular cloning and characterization of viruses isolated from chimpanzees with pathogenic human immunodeficiency virus type 1 infections.
(1998)We have previously described the development of AIDS in a chimpanzee (C499) infected with human immunodeficiency virus type 1 (HIV-1) and the subsequent pathogenic HIV-1 infection in another chimpanzee (C455) transfused ... -
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of NairobiDepartment of Infectious Diseases, 2011-06)Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ... -
Molecular detection and genetic characterization of kobuviruses and astroviruses in asymptomatic local pigs in East Africa
(University of Nairobi., 2013-12)In this study, swine fecal specimens (n = 251) collected from nursing and weaned piglets raised under smallholder production systems were screened for the presence of kobuviruses by RT-PCR. Porcine kobuviruses were detected ... -
Molecular detection of enterotoxigenic escherichia coli surface antigens from patients in Machakos district hospital, Kenya
(University of Nairobi, 2014)Introduction: Enterotoxigenic Escherichia coli (ETEC) is known for its public health importance globally, however, a protective vaccine is yet to be developed. Information regarding the immunology of ETEC’s ... -
Molecular diversity of HIV-1 and prevalence of hepatitis B and C viruses among HIV-infected patients from selected districts in western Kenya
(University of NairobiCollege of Health Sciences,University of Nairobi, 2010-10) -
Molecular epidemiology of measles virus in Kenya.
(University of Nairobi.Department of Paediatrics, 2003-12)Measles causes significant morbidity and mortality globally. Many countries have embarked on immunization programs to control and prevent measles outbreaks and eventually to eliminate endemic measles. Kenya is currently ... -
Molecular epidemiology of Theileria orientalis in Australia and development of a molecular method for differentiation of T. orientalis genotypes
(Department of Biochemistry, 2011) -
Molecular evidence confirms occurrence of Rhipicephalus microplus Clade A in Kenya and sub-Saharan Africa.
(University of Nairobi, 2020)Background The tick vector Rhipicephalus microplus which transmits Babesia spp. and rickettsial pathogens has not been reported in Kenya since 1998. More recently, the pathogenic Babesia bovis has been detected in cattle ... -
Molecular Genetic Analysis Of FIH-1, FH, And SDHB Candidate Tumour Suppressor Genes In Renal Cell Carcinoma.
(Department of Biochemistry, 2004-07)Overexpression of the hypoxia inducible factor 1 (HIF-1) and HIF-2 transcription factors and the consequent upregulation of hypoxia inducible mRNAs is a feature of many human cancers and may be unrelated to tissue hypoxia. ... -
Molecular interactions in the phenomenology of the onset of mental illness
(University of Nairobi, 1973-07)The requirements for a normal functioning of the central nervous system (CNS) are discussed with particular reference to the rigorous separation among central neurotransmitters. Any leak of a transmitter into synapses of ... -
Molecular Methods for Mycobacterium tuberculosis strain typing-Users guide. J Appl Microbio 94:781-791
(University of NairobiSchool of medicine, 2003)No abstract available -
Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa
(University of NairobiCollege of Health Sciences, 2003-12)The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the ... -
Molecular Profiling of Kenyan Acute Myeloid Leukemia Patients
(University of Nairobi, 2022)Acute myeloid leukemia (AML) is an infrequent disease, and it is associated with high morbidity and mortality. It harbors a unique configuration of cytogenetic abnormalities and molecular mutations that can be detected ... -
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes.
(Penn State Hershey Cancer Institute, Milton S. Hershey Medical College, Hershey, PA, USA., 2008)T-cell large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of CD3(+)CD8(+) cells. Leukemic LGLs correspond to terminally differentiated effector-memory cytotoxic T lymphocytes (CTLs) that escape ... -
The molecular relationship between HBV infection and hepatoma in Kenya.
(University of NairobiSchool of medicine, 1985)