Now showing items 1-2 of 2

    • CRISPR detection of circulating cell-free Mycobacterium tuberculosis DNA in adults and children, including children with HIV: a molecular diagnostics study 

      Huang, Zhen; LaCourse, Sylvia M; Kay, Alexander W; Stern, Joshua; Escudero, Jaclyn N; Youngquist, Brady M; Zheng, Wenshu; Vambe, Debrah; Dlamini, Muyalo; Mtetwa, Godwin; Cranmer, Lisa M; Njuguna, Irene; Wamalwa, Dalton C; Elizabeth, Maleche-Obimbo; Catanzaro, Donald G; Lyon, Christopher J; Grace, John-Stewart; DiNardo, Andrew; Mandalakas, Anna M; Ning, Bo; Hu, Tony Y (University of Nairobi, 2022-07)
      Background: Tuberculosis remains a leading cause of global mortality, especially for adults and children living with HIV (CLHIV) underdiagnosed by sputum-based assays. Non-sputum-based assays are needed to improve tuberculosis ...
    • Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis 

      LaCourse, Sylvia M; Leon, Daniel; Panpradist, Nuttada; Richardson, Barbra A; Maleche-Obimbo, Elizabeth; Mecha, Jerphason; Matemo, Daniel; Escudero, Jaclyn N; Kinuthia, John; Lutz, Barry; John-Stewart, Grace (University of Nairobi, 2021)
      We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite ...