Browsing Faculty of Health Sciences (FHS) by Author "Lajoie, Julie"

Now showing items 1-6 of 6

    • Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract 

      Juno, Jennifer A; Lajoie, Julie; Stalker, Andrew T; Oyugi, Julius; Kimani, Makobu; Kimani, Joshua; Plummer, Francis A; Fowke, Keith R (University of Nairobi, 2014-12)
      Problem The expression of inhibitory markers such as LAG-3 and PD-1 on T lymphocytes regulates immune function. Their expression at the genital mucosa is poorly understood, but regulation of immune activation at the ...

    • Hydroxychloroquine reduces T cells activation recall antigen responses 

      Kowatsch, Monika M; Lajoie, Julie; Mwangi, Lucy; Omollo, Kenneth; Oyugi, Julius; Hollett, Natasha; Kimani, Joshua; Fowke, Keith R (University of Nairobi, 2023)
      Background: In the context of the current COVID-19 pandemic, there is still limited information about how people suffering from autoimmune diseases respond to the different COVID vaccines. The fact that they are taking an ...

    • Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells Is associated with viral control 

      Taborda, Natalia A.; Hernández, Juan C.; Lajoie, Julie; Juno, Jennifer A.; Kimani, Joshua; Rugeles, María T; Fowke, Keith R. (University of Nairobi, 2015)
      Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the ...

    • Medroxyprogesterone Acetate Alters The Vaginal Microbiota And Microenvironment In Women And Increases Susceptibility To Hiv-1 In Humanized Mice 

      Wessels, Jocelyne M; Lajoie, Julie; Hay Cooper, Maeve I; Omollo, Kenneth; Felker, Alison M; Danielle, Vitali; Dupont, Haley A; Nguyen, Philip V; Mueller, Kristen; Vahedi, Fatemeh; Kimani, Joshua; Oyugi, Julius; Cheruiyot, Juliana; Mungai, John N; Dashiere, Alexandre; Tremblay, Michel J; Mazzulli, Tony; Stearns, Jennifer; Ashkar, Ali A; Fowke, keith R; Surette, Michael G; Kaushic, Charu (Medroxyprogesterone Acetate Alters The Vaginal Microbiota And Microenvironment In Women And Increases Susceptibility To Hiv-1 In Humanized Mice, 2019)
      The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota ...

    • Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate 

      Frideborg, Bradley; Boger, Mathias F; Kaldhusdal, Vilde; Åhlberg, Alexandra; Edfeldt, Gabriella; Lajoie, Julie; Bergström, Sofia; Omollo, Kenneth; Damdimopoulos, Anastasios; Czarnewski, Paulo; Månberg, Anna; Oyugi, Julius; Kimani, Joshua; Nilsson, Peter; Fowke, Keith; Tjernlund, Annelie; Brolide, Kristina (University of Nairobi, 2022-05)
      Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used by millions of women worldwide. However, experimental studies have associated DMPA use with genital epithelial barrier disruption and ...

    • Regular use of depot medroxyprogesterone acetate causes thinning of the superficial lining and apical distribution of HIV target cells in the human ectocervix 

      Edfeldt, Gabriella; Lajoie, Julie; Rohl, maria; Oyugi, Julius; Ahlberg, Alexandra; Khalilzadeh-binicy, Behnaz; Bradley, Frideborg; Mark, Mathias; Kimani, Joshua; Omollo, Kenneth; Wahlby, Carolina; Fowke, keith R; Broliden, Kristina; Tjernlund, Annelie (University of Nairobi, 2020)
      Background: The hormonal contraceptive depot medroxyprogesterone acetate (DMPA) may be associated with an increased risk of acquiring human immunodeficiency virus (HIV). We hypothesize that DMPA use influences the ectocervical ...