Browsing Faculty of Health Sciences (FHS) by Author "Ochong, E"
Now showing items 1-3 of 3
-
Chloroquine resistance before and after its withdrawal in Kenya
Mwai, L; Ochong, E; Abdirahman, A; Kiara, SM; Ward, S; Kokwaro, G; Sasi, P; Marsh, K; Borrmann, S; Mackinnon, M; Nzila, A (University of NairobiCollege of Humanities Sciences, 2009)Background The spread of resistance to chloroquine (CQ) led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal was followed by a rapid reduction in the frequency of ... -
Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa
Ochong, E; Nzila, A; Kimani, S; Kokwaro, G; Mutabingwa, T; Watkins, W; Marsh, K (University of NairobiCollege of Health Sciences, 2003-12)The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the ... -
The role of sequential administration of sulphadoxine/pyrimethamine following quinine in the treatment of severe falciparum malaria in children
Ogutu, BR; Nzila, AM; Ochong, E; Mithwani, S; Wamola, B; Olola, CH; Lowe, B; Kokwaro, G; Marsh, K; Newton, CR (University of NairobiSchool of Medicine, 2005)Sulphadoxine/pyrimethamine (SP) is often administered with quinine in the treatment of severe falciparum malaria to shorten the course of quinine. The efficacy of SP alone in the treatment of non-severe malaria has been ...