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Comparison of techniques for HIV-1 RNA detection and quantitation in cervicovaginal secretions.
(University of Nairobi., 2001-02)
PRINCIPLES:
HIV-1 in female genital secretions has been measured using swabs, Sno Strips (Akorn, Inc., Buffalo Grove, IL), and cervicovaginal lavage (CVL), but little is known regarding the comparability of these collection ...
Timing of breast milk HIV-1 transmission: a meta-analysis
(2001-02)
:
To define the frequency and timing of breast milk transmission of HIV-1.
DESIGN:
Meta-analysis of data abstracted from published literature.
SUBJECTS:
Participants in prospective cohort studies of MTCT ...
Prevalence and magnitude of human immunodeficiency virus (HIV) type 1-specific lymphocyte responses in breast milk from HIV-1-seropositive women.
(2003)
Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during ...
Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding.
(University of Nairobi., 2007-03)
Previous studies of HIV-1 variants transmitted from mother-to-infant have focused primarily on computational analyses of partial envelope gene sequences, rather than analyses of functional envelope variants. There are very ...
Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant
(University of Nairobi., 2006-01)
Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human ...
Performance of Clinical Algorithms for HIV-1 Diagnosis and Antiretroviral Initiation among HIV-1-Exposed Children Aged Less Than 18 Months in Kenya
(2009-04)
Background
Ninety percent of HIV-1-infected children live in sub-Saharan Africa. In the absence of diagnosis and antiretroviral therapy (ART), approximately 50% die before 2 years.
Methods
We evaluated sensitivity ...
Maternal SDF1 3'A polymorphism is associated with increased perinatal human immunodeficiency virus type 1 transmission
(University of Nairobi., 2000-07)
Genetic polymorphisms in chemokine and chemokine receptor genes influence susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and disease progression, but little is known regarding the association between ...
Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection
(University of Nairobi., 2003-06)
Steady-state levels of human immunodeficiency virus type 1 (HIV-1) RNA in plasma reached at approximately 4 months postinfection are highly predictive of disease progression. Several studies have investigated viral levels ...
Antenatal couple counselling increases uptake of intervention to prevent HIV-1 tranmission
(2004-12)
To determine effect of partner involvement and couple counseling on uptake of interventions to prevent HIV-1 transmission, women attending a Nairobi antenatal clinic were encouraged to return with partners for voluntary ...
Subtype C Is associated with increased vaginal shedding of HIV-1.
(2005-08-01)
The prevalence of human immunodeficiency virus (HIV)-1-infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and ...