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Effect of intrauterine device use on cervical shedding of HIV-1 DNA.
(1999)
OBJECTIVE:
Hormonal contraception has been associated with an increased prevalence of cervical shedding of HIV-1 DNA among infected women. We conducted this study to evaluate the effect of the use of an intrauterine device ...
Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding.
(University of Nairobi., 2007-03)
Previous studies of HIV-1 variants transmitted from mother-to-infant have focused primarily on computational analyses of partial envelope gene sequences, rather than analyses of functional envelope variants. There are very ...
Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant
(University of Nairobi., 2006-01)
Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human ...
Rapid method for screening dried blood samples on filter paper for human immunodeficiency virus type 1 DNA
(University of Nairobi., 1992-02)
PCR is a highly sensitive method for the detection of human immunodeficiency virus type 1 (HIV-1) nucleic acids in blood mononuclear cells and plasma. However, blood separation techniques require extensive laboratory support ...
Maternal SDF1 3'A polymorphism is associated with increased perinatal human immunodeficiency virus type 1 transmission
(University of Nairobi., 2000-07)
Genetic polymorphisms in chemokine and chemokine receptor genes influence susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and disease progression, but little is known regarding the association between ...
Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection
(University of Nairobi., 2003-06)
Steady-state levels of human immunodeficiency virus type 1 (HIV-1) RNA in plasma reached at approximately 4 months postinfection are highly predictive of disease progression. Several studies have investigated viral levels ...
Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial.
(University of Nairobi,, 2004)
Cross-sectional analyses have associated vitamin A deficiency with genital shedding of herpes simplex virus (HSV) among human immunodeficiency virus type 1 (HIV-1)-infected women. A randomized clinical trial of vitamin A ...
Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya.
(University of Nairobi., 1999-05)
If human immunodeficiency virus type 1 (HIV-1) vaccines are to be highly effective, it is essential to understand the virologic factors that contribute to HIV-1 transmission. It is likely that transmission is determined, ...
Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women.
(University of Nairobi, 2020)
A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is the source of viral rebound upon ART cessation and the major barrier to a cure. Understanding reservoir seeding dynamics ...
A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy
(University of Nairobi, 2014-05)
Depot medroxyprogesterone acetate (DMPA) use among HIV-1 infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma ...