Search
Now showing items 21-30 of 36
Global Distribution of Human Protoparvoviruses
(BMC, 2018-07-07)
Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been ...
Development of a luciferase based viral inhibition assay to evaluate vaccine induced CD8 T-cell responses.
(Universty of Nairobi, 2013-11)
Emergence of SIV and HIV specific CD8 T cells has been shown to correlate with control of in vivo replication. Poor correlation between IFN-γ ELISPOT responses and in vivo control of the virus has triggered the development ...
Cytokine and chemokine expression profiles in response to Mycobacterium tuberculosis stimulation are altered in HIV-infected compared to HIV-uninfected subjects with active tuberculosis.
(University of Nairobi, 2015-05-22)
Mycobacterium tuberculosis (Mtb) infects nearly 2 million people annually and is the most common cause of death in HIV-infected individuals. Tuberculosis (TB) diagnostics cater to HIV-uninfected individuals in non-endemic ...
Recombination following superinfection by HIV-1.
(University of nairobi, 2004)
Background: There is increasing recognition of recombinant HIV-1 strains globally, but it has been unclear whether recombination results from superinfection during untreated, chronic infection.
Objective: To search for ...
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
(University of Nairobi, 2014)
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ...
Mucosal blood group antigen expression profiles and HIV infections A Study among female sex workers in Kenya.
(University of Nairobi, 2015-07)
Background
The ABO blood group antigens are carbohydrate moieties expressed on human red blood
cells however; these antigens can also be expressed on some other cells particularly the
surface of epithelial cells and may ...
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
(2016)
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the ...
Pregnancy rates among female participants in phase I and phase IIA AIDS vaccine clinical trials in Kenya
(2009-09)
Background: Female participants in AIDS candidate vaccine clinical trials must agree to use effective contraception to be enrolled into the studies, and for a specified period after vaccination, since the candidate vaccines’ ...
Novel Approach For Differential Diagnosis Of Hiv Infections In The Face Of Vaccine-generated Antibodies: Utility For Detection Of Diverse Hiv-1 Subtypes.
(University of Nairobi, 2006)
Because increasing numbers of HIV vaccine candidates are being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Most of the currently tested vaccines contain multiple viral components. ...
National burden of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness in Kenya, 2012-2014.
(University of Nairobi, 2017)
BACKGROUND:
Influenza-associated respiratory illness was substantial during the emergence of the 2009 influenza pandemic. Estimates of influenza burden in the post-pandemic period are unavailable to guide Kenyan vaccine ...